Browsing by Author "Talaz, Oktay"
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alpha-Carbonic anhydrases are sulfatases with cyclic diol monosulfate esters
Cavdar, Huseyin; Ekinci, Deniz; Talaz, Oktay; Saracoglu, Nurullah; Senturk, Murat; Supuran, Claudiu T. (TAYLOR & FRANCIS LTD, 2012)Carbonic anhydrases (CA) catalyze activated ester hydrolysis in addition to the hydration of CO 2 to bicarbonate. They also show phosphatase activity with 4-nitrophenyl phosphate as substrate but not sulfatase with the ... -
Determination of the inhibitory effects of N-methylpyrrole derivatives on glutathione reductase enzyme
Kocaoğlu, Esma; Talaz, Oktay; Çavdar, Hüseyin; Şentürk, Murat; Supuran, Claudiu T.; Ekinci, Deniz (Taylor and Francis, 2019)Glutathione reductase (GR) is a crucial antioxidant enzyme which is responsible for the maintenance of antioxidant GSH molecule. Antimalarial effects of some chemical molecules are attributed to their inhibition of GR, ... -
Structure-activity relationships for the interaction of 5,10-dihydroindeno[1,2-b] indole derivatives with human and bovine carbonic anhydrase isoforms I, II, III, IV and VI
Ekinci, Deniz; Cavdar, Huseyin; Durdagi, Serdar; Talaz, Oktay; Senturk, Murat; Supuran, Claudiu T. (ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2012)Several 5,10-dihydroindeno[1,2-b]indole derivatives incorporating methoxy, hydroxyl, and halogen (F, Cl, and Br) moieties on the indene fragment of the molecule were prepared and tested against five carbonic anhydrase (CA, ... -
Synthesis of novel mono and bis-indole conduritol derivatives and their alpha/beta-glycosidase inhibitory effects
Cavdar, Huseyin; Talaz, Oktay; Ekinci, Deniz (PERGAMON-ELSEVIER SCIENCE LTD, 2012)Here we synthesized four novel indole conduritol derivatives 1-4 for the first time in the literature and probed their biological activities with the alpha and beta-glucosidases. The compounds showed quite effective ...
