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dc.contributor.authorÖzlem Fentoğlu
dc.contributor.authorFatma Yeşim Kırzıoğlu
dc.contributor.authorMemduha Bulut Tözüm
dc.contributor.authorŞivge Kurgan
dc.contributor.authorMeral Günhan
dc.contributor.authorHavva Koçak
dc.contributor.authorRecep Sütcü
dc.contributor.authorBanu Köroğlu Kale
dc.date.accessioned30.04.201910:49:13
dc.date.accessioned2019-07-13T16:31:35Z
dc.date.available30.04.201910:49:13
dc.date.available2019-07-13T16:31:35Z
dc.date.issued2015
dc.identifier.issn1300-0144
dc.identifier.urihttps://trdizin.gov.tr/publication/paper/detail/TVRjeU56QTVPUT09
dc.identifier.urihttps://hdl.handle.net/20.500.12438/1696
dc.description.abstractBackground/aim: To evaluate the effects of periodontal treatment on serum lipoprotein-associated phospholipase A2 (Lp-PLA2) and C-reactive protein (CRP) levels in hyperlipidaemic patients with periodontitis. Materials and methods: The study included 52 hyperlipidaemics and 28 systemically healthy controls (C) with periodontitis. Of the 52 hyperlipidaemics, 29 received a suggested diet (HD), and 23 of them were prescribed statin (HS). Clinical periodontal parameters, serum lipids, Lp-PLA2, and CRP levels were assessed at the baseline and 2 months after the completion of the nonsurgical periodontal treatment (2MPT). Serum parameters were also evaluated 1 week following the periodontal treatment (1WPT). Results: At the baseline, patients in the HS group had a higher percentage of bleeding on probing than those in the C and HD groups. Hyperlipidaemics had higher serum triglyceride levels than the control group at 2MPT compared to the baseline. At 2MPT, the levels of Lp-PLA2 in the HS group were significantly higher compared to the baseline and 1WPT. There were no statistically significant differences in CRP levels between study periods for all groups. Conclusion: The periodontal treatment may affect the inflammatory control of hyperlipidaemic patients with periodontitis via increased Lp-PLA2 levels and severity of the impaired lipid metabolism. These findings may be important regarding the therapeutic strategies for hyperlipidaemics with periodontitis.en_US
dc.description.abstractBackground/aim: To evaluate the effects of periodontal treatment on serum lipoprotein-associated phospholipase A2 (Lp-PLA2) and C-reactive protein (CRP) levels in hyperlipidaemic patients with periodontitis. Materials and methods: The study included 52 hyperlipidaemics and 28 systemically healthy controls (C) with periodontitis. Of the 52 hyperlipidaemics, 29 received a suggested diet (HD), and 23 of them were prescribed statin (HS). Clinical periodontal parameters, serum lipids, Lp-PLA2, and CRP levels were assessed at the baseline and 2 months after the completion of the nonsurgical periodontal treatment (2MPT). Serum parameters were also evaluated 1 week following the periodontal treatment (1WPT). Results: At the baseline, patients in the HS group had a higher percentage of bleeding on probing than those in the C and HD groups. Hyperlipidaemics had higher serum triglyceride levels than the control group at 2MPT compared to the baseline. At 2MPT, the levels of Lp-PLA2 in the HS group were significantly higher compared to the baseline and 1WPT. There were no statistically significant differences in CRP levels between study periods for all groups. Conclusion: The periodontal treatment may affect the inflammatory control of hyperlipidaemic patients with periodontitis via increased Lp-PLA2 levels and severity of the impaired lipid metabolism. These findings may be important regarding the therapeutic strategies for hyperlipidaemics with periodontitis.en_US
dc.language.isoengen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCerrahien_US
dc.titleSerum Lp-PLA2: as a novel viewpoint in periodontal treatment of hyperlipidaemicsen_US
dc.typearticleen_US
dc.relation.journalTurkish Journal of Medical Sciencesen_US
dc.departmentKütahya Dumlupınar Üniversitesien_US
dc.identifier.volume45en_US
dc.identifier.issue3en_US
dc.identifier.startpage619en_US
dc.identifier.endpage626en_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US]


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