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dc.contributor.authorÇetiner, Mustafa
dc.contributor.authorAydın, Hasan Emre
dc.date.accessioned2019-12-24T17:11:30Z
dc.date.available2019-12-24T17:11:30Z
dc.date.issued2018
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.urihttps://dx.doi.org/10.3906/sag-1806-236
dc.identifier.urihttp://www.trdizin.gov.tr/publication/paper/detail/TWprNU1EQTJOZz09
dc.identifier.urihttps://hdl.handle.net/20.500.12438/2809
dc.description.abstractBackground/aim: The aim of this study was to investigate the effects of valproic acid (VPA) and a new-generation antiepileptic drugcalled brivaracetam (BRV) on the brain damage occurring after status epilepticus (SE) in rats.Materials and methods: In our study, an experimental animal model of SE, generated by stereotaxically injecting 0.4–2 µg of kainicacid into the rat hippocampus, was used. The laboratory animals were divided into 4 groups: the first group was a sham group thatwas subjected to anesthesia and SE was not induced; the second group was a SE group, in which SE was induced using kainic acid butsubjects were not treated; the third group was the VPA group, in which SE was induced using kainic acid and subjects were treated withVPA; and the fourth group was the BRV group, in which SE was induced using kainic acid and subjects were treated with BRV.Results: Annexin V and p53 levels were statistically higher in the SE group than in the sham group (P 0.001). Following the treatmentwith VPA and BRV, a substantial decrease was observed in the annexin V and p53 levels compared to those of the SE group (P 0.001).There was a statistically significant increase in Bcl-2 levels after VPA and BRV treatment compared to the SE group (P 0.001).Conclusion: Our study showed that VPA and BRV are protective against neuronal damage occurring after SE in rats due to the increasein Bcl-2.en_US
dc.language.isoengen_US
dc.relation.isversionof10.3906/sag-1806-236en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCerrahien_US
dc.subjectRaten_us
dc.subjectStatus Epilepticusen_us
dc.subjectApoptosisen_us
dc.subjectValproic Aciden_us
dc.subjectBrivaracetamen_us
dc.titleDemonstration of the effect of brivaracetam on an experimental epilepsy modelen_US
dc.typearticleen_US
dc.relation.journalTurkish Journal of Medical Sciencesen_US
dc.departmentDumlupınar Üniversitesien_US
dc.identifier.volume48en_US
dc.identifier.issue6en_US
dc.identifier.startpage1315en_US
dc.identifier.endpage1320en_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.cont.department-tempDumlupınar Üniversitesi Tıp Fakültesi, Nöroloji Anabilim Dalı, Kütahya, Türkiye;Dumlupınar Üniversitesi, Tıp Fakültesi, Beyin Cerrahisi Anabilim Dalı Kütahya, Türkiyeen_US


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