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dc.contributor.authorÖzer, Abdullah
dc.contributor.authorDemirtaş, Hüseyin
dc.contributor.authorÇomu, Faruk Metin
dc.contributor.authorErer, Dilek
dc.contributor.authorKılıç, Yiğit
dc.contributor.authorMardin, Barış
dc.contributor.authorArslan, Mustafa
dc.date.accessioned2019-12-24T17:15:02Z
dc.date.available2019-12-24T17:15:02Z
dc.date.issued2018
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.urihttps://dx.doi.org/10.3906/sag-1706-160
dc.identifier.urihttp://www.trdizin.gov.tr/publication/paper/detail/TWprNU1UWTFOUT09
dc.identifier.urihttps://hdl.handle.net/20.500.12438/3132
dc.description.abstractBackground/aim: The protective effect of erdosteine on local and distant organ injury due to ischemia/reperfusion has been welldocumented but its effect on erythrocyte deformability needs further investigation. Our aim was to investigate the effect of erdosteineon erythrocyte deformability in the infrarenal aorta of rats undergoing ischemia/reperfusion.Materials and methods: Our study was conducted with 18 Wistar albino rats. Rats were divided into 3 groups: a randomized controlgroup (group ‘control’, n 6), an ischemia/reperfusion group without erdosteine (group ‘ischemia/reperfusion’, n 6), and an ischemia/reperfusion group with erdosteine at 150 mg kg–1, intraperitoneally (group ‘ischemia/reperfusion – erdosteine’, n 6). Packs oferythrocytes were prepared from heparinized blood samples and deformability measurements were conducted.Results: Comparisons of the control and ischemia/reperfusion – erdosteine groups revealed similar results (P 0.051). The values ofthe ischemia/reperfusion group were significantly higher than those of the control and ischemia/reperfusion – erdosteine groups (P 0.0001 and P 0.024, respectively). Relative resistance, a marker of erythrocyte deformability, was increased significantly by ischemia/reperfusion compared to the control and ischemia/reperfusion – erdosteine groups (P 0.05).Conclusion: We detected unfavorable effects of ischemia/reperfusion on erythrocyte deformability, which may lead to disturbancein blood flow and hence tissue perfusion in the infrarenal rat aorta. We also found that erdosteine had beneficial effects by reversingundesirable effects of ischemia/reperfusion. However, these promising results should be further supported by more detailed studies withlarger volumes.en_US
dc.language.isoengen_US
dc.relation.isversionof10.3906/sag-1706-160en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCerrahien_US
dc.subjectErythrocyte Deformabilityen_us
dc.subjectİschemia Reperfusion İnjuryen_us
dc.subjectErdosteineen_us
dc.subjectLower Limben_us
dc.titleProtective effect of erdosteine on erythrocyte deformability in a rat model of lower limb ischemia/reperfusion injuryen_US
dc.typearticleen_US
dc.relation.journalTurkish Journal of Medical Sciencesen_US
dc.departmentDumlupınar Üniversitesien_US
dc.identifier.volume48en_US
dc.identifier.issue1en_US
dc.identifier.startpage187en_US
dc.identifier.endpage190en_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.cont.department-tempGazi University Medical Faculty, Department of Cardiovascular Surgery, Ankara, Turkey;Yüksek İhtisas Hastanesi, Kalp Damar Cerrahisi Kliniği, Kırıkkale, Türkiye;Kırıkkale Üniversitesi, Tıp Fakültesi, Fizyoloji Anabilim Dalı, Kırıkkale, Türkiye;Gazi University Medical Faculty, Department of Cardiovascular Surgery, Ankara, Turkey;Iğdır Devlet Hastanesi, Kalp Damar Cerrahisi Anabilim Dalı, Iğdır, Türkiye;Gazi University Medical Faculty, Department of Cardiovascular Surgery, Ankara, Turkey;Gazi Üniversitesi, Tıp Fakültesi, Anesteziyoloji ve Reanimasyon Anabilim Dalı, Ankara, Türkiye;Dumlupınar Üniversitesi, Tıp Fakültesi, Fizyoloji Anabilim Dalı, Kütahya, Türkiye;Gazi Üniversitesi Tıp Fakültesi, Kalp Damar Cerrahisi Anabilim Dalı, Ankara, Türkiyeen_US


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